Mark Purdey    Seeking the truth through Science!

HomeMark Purdey - Tributes - Mark Purdey's Book ' Animal Pharm'  - ArticlesScience - Research FundNews - Politics
Site Map  -  FAQ'sContactsSearchLinks


Trail:

Ultra Violet

page 2

page 3

page 4

page 5

page 6

page 7

page 8

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Scientific papers - Ultra Violet page 8


ACKNOWLEDGEMENTS
Thanks to Nigel Purdey (London), Dr David Brown (Cambridge), Professor Michel Bounias (Avignon), Professor Sigurdur Sigurdarson (Keldur), Professor Maurizio Pocchiari (Rome), Professor Bob Will (Edinburgh), Dr Eva Mitrova (Bratislava), V1adimira Popikova (Svidnik), Dr Ciriaco Ligios (Sassari), Dr Giuseppe Ru (Torino) for discussion and assitance.

REFERENCES
1 . Bastian F. CJD and other transmissible spongiform encephalopathies. St Louis: Mosby Year Book; 199 1.
2. Collinge J., Palmer M. S., eds. Prion Diseases Oxford. Oxford University Press, 1997
3. Purdey M. The UK epidemic of BSE: slow virus or chronic pesticide initiated modification of the prion protein (Parts 1 and 2). Med Hypotheses 1996; 46: 429-454.
4. Purdey M. Ecosystems supporting clusters of sporadic TSEs demonstrate excesses of the radical generating divalent cation manganese and deficiencies of antioxidant co
factors Cu, Se, Fe, Zn. Does a foreign cation substitution at PrP's Cu domain initiate TSE? Med Hypotheses 2000; 54(2): 278-306.
5. Brown D., Hafiz E, Glassmith L., et al. Consequences of manganese replacement of copper for prion protein function and proteinase resistance. EMBO J 2000; 19(6): 1180-1186.
6. Brown D., Wong B., Haziz E, Clive C., Haswell S., Jones 1. Normal prion protein has an activity like that of superoxide dismutase. Biochem J 1999; 344: 1 -5.
7 HaIliwell B., Gutteridge J. M. 0., eds. Free Radicals in Biology and Medicine, 2nd ed.n. Oxford: Clarendon Press, 1989.
8. Forman H., Cadenas E., eds. Oxidative Stress and Signal transduction. New York: Chapman and Hall, 1997
9. Aschner M., Aschnerj. L. Manganese neurotoxicity; cellular effects and blood brain barrier transport. Neurosci Biobehav Rev 1991;15:333-340.
10. Barbeau A. Manganese and extra pyramidal disorders. Neurotoxicol 1984; 5(l): 13-36.
11. Martz W, ed. Trace Elements in Human and Animal Nutrition. New York: Academic Press, 1986.
12. Mena 1. Manganese. In: Brouser E, Ford E. D., eds. Disorders of Mineral Metabolism; Vol 1 Trace minerals New York: Academic Press, 1981: 233-270.
13. Cotzias G. Manganese, melanins and the extrapyramidal system. J Neurosurg (Suppl) 1966; 24: 170-180.
14. Huselton C., Hill H. Melanin photosensitises UVC DNA damage in pigmented cells. Env Mol Mutagenesis 1990; 16(l): 37-43.
15. Brown D., Qin K., Herms J. et al. The cellular prion protein binds copper in vivo. Nature 1997; 390: 684-68Z
16. Homshaw XL, McDermott J., Candy J., Lakey J. Copper binding to the N-terminal tandem repeat region of mammalian and avian PrP; Structural studies using synthetic peptides. Biochem Biophys Res. Commun 1995; 214(3): 993-999.
17 Collinge J., Sidle K. C. L., Meads J., Ironside J., Hill A. F. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 1996; 383: 685-690.
18. Alpers M. Kuru. In: Attenborough R. D., Alpers M., eds. Human Biology in Papria New Quinea. Oxford: Clarendon Press, 1992: 312-333.
19. Collinge J. Proceedings of the National Academy of Science 2000, vol. 97, p. 10248.
20. Lidiard H., Rae j., Parker A. Identification of Mn oxide minerals in some soils from Devon, UK, and their varying capacity to absorb Co and Cu. Environ Geochem Illth 1993; 15(2/3): 93-104.
21. Spraker T. R., Miller M. W., Williams E. S., et al. Spongiform encephalopathy in free ranging Mule deer, White-tailed deer and Rocky Mountain Elk in North Central Colorado. J Wildlife Dis 1997; 33(l): 1-6.
22. Williams E. S., Young S. Spongiform encephalopathies in Cervidae. Rev Sci lech OffIntEpiz 1992; 11(2): 551-567
23. Barrick K. A., Schoettle A. W A comparison of the foliar nutrient status of elfinwood and symmetrically formed tall
trees, Colorado Front Range, USA. Can j Bot 1996; 74: 1461-1475.
24. Sisler J. F. Spatial and seasonal patterns and long term variability of the composition of the haze in the USA; an analysis of
data from the IMPROVE network. July 1996. ISSN; 0737-5352-32. CIRA, Colorado State University, Fort Collins, CO 80523, USA.
25. Sisler J. E, Huffinan D., Spatial and temporal patterns and the chemical composition of the haze in the USA; An analysis of
data from the improve network 1988-1991. February 1993. ISSN no 0737-5352-26. CIRA Foothills Campus, Colorado State University, Fort Collins, CO 80523, USA.
26. Park C. Acid Rain. London: Methuen, 1987
27 Mitrova E. Some new aspects of CJD epidemiology in Slovakia. EurJEpidemiol 1991; 7(5): 439-449.
28. Mayer V., Orolin D., Mitrova E., Lehotsky T. Transmissible virus dementia. 1. An unusual space and time clustering of CJD and of other organic presenile dementia cases. Acta Virol 1978; 22: 146-153.
29. Mitrova E, Bronis M. Clusters of Q1) in Slovakia; the first statistically significant temporo-spatial accumulations of rural cases. EurJ Epidemiol 1991; 7(5): 450-456.
30. Mitrova E., Huncaga S., Hocman G. Clusters of CJD in Slovakia 11; The first evidence of scrapie in Czecko-Slovakia.
Eur J Epidemiol 1991; 7(5): 457-467
31. Nosal R., Kapoor A., Shanin R. Cluster of cases of CJD in Ontario. Can Disp Weekly 199 1; jan 1, Report 17(3): 12.
32. Sigurdarson S. Epidemiology of scrapie in Iceland and experience with control measures. In: Bradley R., ed. Sub Acute
Spongiform Encephalopathies. Brussels and Luxembourg: ECSC EEC EAEC, 1991: 233-242.
33. Palsson R A. Rida (scrapie) in Iceland and its epidemiology in: Slow transmissible diseases of the nervous system, vol. 1.
London: Academic Press, 1979: 357-366.
34. D'Alessandro M., Petraroli R., Ladogana A., Pocchiari M. High incidence of CJD in rural Calabria, Italy. Lancet 1998; 352: 1989-1990.
35 Tanaka S., Lichen J., Harrisburg P. Mn poisoning and exposure in Pennsylvania Arch Environ Health 1969; 19: 674-684.
36 Cianutsos G., Morrow G. R., Morris J. B. Accumulation of Mn in rat brain following intranasal administration. Fund Appl Toxicol 1997; 37(2): 102-105.
37. Trace minerals: manganese. Roche'Vitec' Information Sheet Al 4/1, May 1987
38. Usage of raw materials in Animal feeds in Great Britain 1984-1995 or personal letters - Alex Clothier, MAFF Statistics,
Foss House, Kings Pool, 1-2 Peasholme Green, York, YO 1 2PX, UK.
39. Eley XL, Nicholson K. Chemistry and adsorption-desorption properties of Mn oxides deposited in Forehill water treatment plant, Grampian, Scotland. Environ Geochem Health 1993; 15 (2/3): 85-91 .
40. Sly J. M. A. Review of usage of pesticides in Agriculture and horticulture in England and Wales 1975-1979. Report No 23. London: MAFF Publications, 1981
41. Sly J. M. A. (Agricultural Development and Advisory Service, Hatching Green, Harpenden, Herts.)
Review of usage of pesticides in Agriculture and horticulture in the UK; Report No 41. London: M-AFF Publications, 1985.
42. Thomas M. R. Review of usage of pesticides in agriculture and horticulture throughout GB 1984-1994. Pesticide Usage Survey Report 100: London: MAFF Publications, 1997
43. Trace Elements in soils and crops. Technical Bulletin 2 1. London: MAFF HMSO, 1971.
44. Environmental Health Criteria 17: Manganese. IPCS International Programme on Chemical Saftey. Geneva: World Health Organization, 1986.
45. Brown D., Schulz-Schaeffer W. J., Schmidt B., Kretzschmar H. A. PrP deficient cells show altered response to oxidative stress due to decreased SOD- 1 activity. Exper Neurol 1997; 146: 104-112.
46. Brown D., Wong B., Jones 1. Recombinant PrP exhibits superoxide dismutase activity. J Neurochem 1999; 73 (19).
47 Banta R. G., Markesbury W. R. Elevated Mn levels associated with dementia and extrapyramidal signs. Neurology 1977; 27: 213-216.
48. Abdel Naby S., Hassanein M. Neuropsychiatric manifestations of chronic manganese poisoning. J Neurol Neurosurg Psychiat 1965; 28:282-288.
49. Ashizawa R. Ueber emen Sektionsfall von chronischer manganvergiffungen. jap J Med Sci Trans. sect. V1 11 Intern Med Pediat Psychiat 1927; 1: 173-19 1.
50. Trendtel F. Zur Frage des Manganismus. Mschr unfallheilk 1936; 43: 69-84.
51. Canavan M. M., Cobb S., Drinker C. K. Chronic manganese poisoning; report of a case with autopsy.
Arch Neurol Psychiat (Chicago) 1934; 32: 501-513
52. Gibbons R. A., Dixon S. N., Hallis K., Russell A. M., Sansom B. E, Symonds H.W. Mn metabolism in cows and goats.
Biochim Biophys Acta 1976; 444: 1 - 10.
53. Patel B. N., David S. A novel GPI anchored form of ceruloplasmin expressed by astrocytes. J Biol Chem 1997; 272 (32): 20185-20190.
54. Kimmerle G.,Loeser E. Delayed neurotoxicity of OP compounds and Cu concentrations in the serum of hens.
Environ Qual Safety 1974; 3: 173-179.
55. Carruthers M. B., Hobbs G. B., Warcen R. B. Raised ceruloplasmin levels in subjects taking oral contraceptives
J Clin Pathol 1966; 19: 498-500.
56. Neff N. H., Barrett R. E. Costa E. Selective depletion of caudate nucleus dopamine and serotonin during chronic Mn dioxide administration to squirrel monkeys. Experientia 1969; 25: 1140-1141.
57 Mustala S. j., Chandra S. V. levels of 5-hyroxytryptamine,dopamine and norepinephrine in whole brain of rabbits in
chronic Mn toxicity. J Neurochem 1971; 18: 931-93 3.
58. Bassant M. Fl., Picard M., Olichon D., Cathala E, Court L. Changes in the serotonergic, noradrenergic and dopaminergic levels in the brain of scrapie-infected rats. Brain Res 1986; 367: 360-363.
59. Cross A. j., Kimberlin R. H., Crow T. j., johnson J. A., Walker C. A. Neurotransmitter metabolites, enzymes and receptors in experimental scrapie. J Neurol Sci 1985; 70: 231-24 1.
60. Brun A., GottIries C. G., Roos B. E. Studies of the monoamine metabolism in the CNS in CJD.
Acta Neurol Scand 1971; 47: 642-645.
61. Nyberg R, Almay B. G. L., CarIsson A., Masters C., Winblad B. Brain monamine abnormalities in two types of CJD.
Acta Neurol Scand 1982; 66: 16-24.
62. Goudsmit J., Rohwer R. G., Silvergeld E. K. Hypersensitivity to central serotonin receptor activation in scrapie infected
hamsters and the effect of serotonergic drugs on scrapie symptoms. Brain Res 198 1; 220: 372-37Z
63. Bost M, Kopp N, Giraud P, Copper status and screening for other trace elements in CJD patients; preliminary results.
J.Alzheimers Disease 2000; 2: poster 27
64. Mena L, Marin 0., Fuenzalida S., Cotzias G. C. Chronic manganese poisoning. Neurol 1967; 17:128-136.
65. Rawal M. L. Manganese poisoning in Mn mines in India. Ind J Industrial Med 1968; 14(2): 41-5 1.
66. Greenhouse A. H. Mn intoxication in the USA. Trans Am Neurol Ass 1971; 96: 248-249.
67 Will R. G., Ironside J. W, Zeidler M. et al. A new variant of CJD in the UK. Lancet 1996; 347: 921-925.
68. De Reuck J., De Coster W, vander Eecken H. QD: a comparative light-microscopic, histochemical and electron microscopic study. EurNeurol 1975; 13: 154-166.
69. Whatley S. A., Powell J. E, Politopoulou G., Campbell I. C., Brammer M. J., Percy N. S. Regulation of intracellular free
calcium levels by the cellular prion protein. Mol Neurosci 1995; 6:2333-2337
70. Kristensson K., Feuerstem E., Taraboulos A., Hyun M., Prusiner S., DeArmond S. Scrapie prions alter receptor-mediated calcium responses in cultured cells. Neurologv 1993; 43: 2335-2341.
71. Robinson N. CJD: a histochemical study. Brain 1969; 92: 581-588.
72. Mackensie A. Intraneuronal enzymic inclusions in the histological diagnosis of scrapie. J Comp Pathol 1984; 94: 9-24.
73. Ikuta E, Kumanishi 1, Ohashi T. Experimental study on CJD. Adv Neurol Sci 1974; 18: 46-6 1.
74. Narang H., Millar N., Asher D., Gajdusek D. increased multimeric mitochondrial DNA in the brain of scrapie-infected hamsters. Intervirology 1991; 32: 316-324.
75. Gabizon R., Prusiner S. Prion liposomes. BiochemJ 1990; 266: 1-14.
76. Stahl N., Baldwin M. A., Teplow D. B., et al. Structural studies of the scrapie prion protein
using mass spectrometry and amino acid sequencing. Biochem 1993; 32: 1991-2002.
77 Hope J., Baybutt H. The key role of the nerve membrane protein PrP in scrapie-like diseases.
Sem Neurosci 1991; 3: 165-171.
78. Diez-Ewald M., Weintraub L., Crosby W. Interrelationship of iron and manganese metabolism.
Proc Soc Exp Biol Med 1968; 129: 448-451.
79. Hancock R., Fritze K. Mn porphyrins in erythrocytes. Bioinorg Chem 1973; 3: 77
80. Pittendrigh C. Circadian oscillations and organisation in nervous system. In: Schmitt E, Wonder E, eds.
The Neurosciences: 3rd Study Program Cambridge, MA: The MIT Press, 1974; 435-537
81 Caughey B. Scrapie associated PrP accumulation and its prevention; insights from cell culture. Brit Med Bull 1993; 49(4):
860-872.
82.Inouye H., Nguyen J.1, FraserP.E., Packard A. B., Kirschner D. A. Histidine residues underlie
congo red binding to A beta analog amyloid. International J Experimental Clin Investigaton 2000;7:179-188.
83. Caughey W, Raymond L., Horiuchi M., Caughey B. Inhibition of protease resistant PrP formation by porphyrins and phthalocyanines. PNSA 1998; 95(2l): 12117-12122.
84.Bounias Xl., Andre J. E, Kruk 1. Synergistic and molecular interactions between the formamidine amitraz and copper (11) sulfate, used against the mite Varroa jacobsoni 0., a parasite of the honeybee Apis mellifera. Biometals 1993; 6: 49-53.
85. Brown D. R, Schmidt B., Kretzschmar H. A. A PrP fragment primes Type 1 astrocytes to proliferation signals from microglia. Neurobiol Dis 1998; 4: 410-422.
86 Menaker M. Rhythms, reproduction and photoreception. Biol Reprod 197 1; 4: 295-3 08.
87 Lisk R., Karmwischer L. Light: evidence for its direct effect hypothalamic neurones. Science 1964; 146: 272-273.
88. Ganong W, Shephard M., Wall j., Van Brunt E., Glegg M. Penetration of light into the brain of mammals. Endocrinology 1963;72:962-963.
89. Devlin T. M., ed. Textbook of Biochemistry with Clinical Correlations, 3rd edn. New York: Wiley-Lisf, 1992.
90. Flynn A., Francmann A. W, Arneson P. D., Oldemever J. L. Indications of Cu deficiency in a subpopulation of Alaskan moose. J Nutri 1977; 107: 1182-1189.
91. Tobler L., Gaus E., Deboer T. et al. Altered circadian activity rhythms and sleep in mice devoid of PrP. Nature 1996; 380: 639-642.
92. Cagampang E R., Whatley S., Powell J. E, Mitchel A. L., Campbell 1. G., Cohen W. Circadian regulation of PrP messenger RNA in rat forebrain; a widespread and synchronous rythmn. Neurosi 1999; 91: 1201-1204.
93. Morton D. J. Alteration of plasma cation levels in rats kept in constant light. J Pineal Res 1990; 9: 95- 10 1.
94. Barnett K., Palmer A. Retinopathy in sheep affected with natural scrapie. Res Vet Sci 1971; 12: 383-385.
95. Hogan R., Kingsbury D., Baringer D. Retinal degeneration in experimental CJD. Lab Invest 1983; 49: 708-715.
96. Hogan R, Baringerj., Prusiner S. Progressive retinal degeneration in scrapie infected hamsters. Lab Invest 198 1; 44: 34-42.
97 Fowler M., Robertson N. Observations on Kuru. 111. Pathological features in 5 cases. AustAnn Med 1959; 8: 16-26.
98. Roth A., Keltner j., Ellis W. Virus simulated structures in the optic nerve head in CJD. Am J Opthalmol 1979; 87: 827-833.
99. Buyukmihci N., Marsh R., Albert D. Ocular effects of scrapie agent in hamsters; preliminary observations.
Invest Ophthalmol 1977;16:319-324.
100. Buyukmffici N., Rorvik M., Marsh R. Replication of the scrapie agent in ocular neural tissues. Proc Natl Acad Sci USA 1980; 77:1169-1171.
101. Foster J., Fraser H., Bruce M. Retinopathy in Mice with experimental scrapie. Neuropath Appl Neurobiol 1986; 12: 185-196.
102. Hogan R. Replication of scrapie prions in hamster eye precedes retinal degeneration. ophthalmol Res 1986; 18: 230-235.
103. Buyukmihci N., Goehring-Hannon E, Marsh R. Neural pathogenesis of experimental scrapie after intraocular inoculation of hamsters. Exp Neurol 1983; 81: 396-406.
104. Buyukmihci N., Goehring-Harmon E, Marsh R. Asymmetry of retinal lesions in experimental scrapie after intracerebral inoculation of hamsters. Exp Neurol 1985; 87: 172-176.
105. Tarkkanen A., Haltia M. CJD. Trans Ophthalmol Soc UK 1980; 100:151-154.
106. Ultra violet Radiation; Environmental health Criteria 14. Geneva: WHO publications, 1979.
107 Akai j., Ishihara 0., Higuchi S. CJD in Japan. Neuroepidemiologv 1989;8:32-3Z
108. Detwiler L. A. Scrapie. Rev Sci Tech OffInt Epiz 1992; 11 (2): 133 491-537
109. Agrimi U., Rm G., Cardone E, Pocchiari M., Caramelli M. Epidemic of TSE in sheep and goats in Italy. Lancet 1999; 353: 134 560-561.
110. Kemp D. Global Environmental Issues, 2nd edn. London: Rowtledge, 1994.
111. Rinette 11, Julicher L., Tijburg L., Aaalt B., Koomen j., Noordhoek J. Decreased defence against free radicals in rat heart during normal rederfusion after hypoxic, ischemic and calcium free perfusion. Life Sci 1984; 35(12): 1281-1288.
112. Dux E., Temesvari R, Joo F. et al. The blood brain barrier in hypoxia. Neurosci 1984; 12(3): 951-958.
113. The Potential Effects of Ozone Depletion in the UK. Dept of Environment HMSO Stationers, London: 1992.
114. Makhijani A., Gurney K. Mending the Ozone Hole. Cambridge, MA: MIT Press, 1995.
115. Ozone in the UK. 3rd Report of the Photochemical Oxidants Review Group. London: HMSO, 1993.
116. Ozone: health hazards and precautionary measures. Health and Saftey Executive. Guidance Note EH 38 (revised) 1996. 139. HSE Books, Sudbury, Suffolk, UK.
117 Collins S., Law M. G., Fletcher A., Boyd A., Caldor j., Masters C. J. Surgical treatment and risk of sporadic CJD; a case control study. Lancet 1999; 353: 693-697
118. Kovanen j., Haltia M. Descriptive epidemiology of CJD in Finland. Acta Neurol Scand 1988; 77: 474-480.
119. Masters G. L., Harris J. 0., Gajdusek C., Gibbs C. J., Bernoulli C., Asher D. M. CJD: Patterns of worldwide occurrence and the significance of familial and sporadic clustering. Ann Neurol 1979; 5: 177-188.
120. CJD surveillance in the UK. 7th Annual Report. National CJD Surveillance Unit, Western General Hospital, Edinburgh EH4 2XU, UK, 1998.
121. CJD Surveillance in the UK. 8th Annual Report. National CJD Surveillance Unit, Western General Hospital, Edinburgh, EH4 143. 2XU, UK, 1999.
122. Diffey R., Gibson C., Haylock R., McKinlay A. Outdoor UV exposure of children and adolescents. Br.J Dermatol 1996; 3: 144 67-82.
123. Diffey B. Analysis of the risk of skin cancer from sunlight and solaria in subjects living in N Europe. Photodermatologv 1987; 4: 118-126.
124. Elwood J. Melanoma and sun exposure: contrast between intermittent and chronic exposure. World J Surg 1992; 16: 157-165.
125. Acheson E. From the chief Medical Officer. Mortality from cutaneous malignant melanoma. Health Trends 1986; 18: 73.
126. Lawrence D., Bennet P., eds. Clinical Pharmacology, 5th edn. New York: Churchill Livingstone, 1980.
127 Yannuzzi L, Fisher Y., Slakter J., Krueger A. Solar retinopathy. Retina 1989; 9: 28-43.
128. MAFF. BSE in Great Britain. A progress report. June 2000. London: MAFF Publications, 2000.
129. Armstrong B., Kricker A. Cutaneous melanoma. Cancer Surveys 1994;19:219-240.
130. Rees H. The British Isles - A Regional Geography. London: George Harrap, 1968.
131. Mackie R., Hunter J. Cutaneous malignant melanoma in Scotland 1979-1989. Lancet 1992; 339: 971-975.
132. Purdey M. High dose exposure to systemic phosmet insecticide modifies the phosphatidylinositol anchor on the prion protein; the origins of new variant transmissible spongiform. encephalopathies. Med Hypotheses 1998; 50: 91-111.
133. Purdey M. Are organo-phosphate pesticides involved in the causation of BSE? Hypothesis based upon a literature review and limited trials on BSE cattle. J Nutri Med 1994; 4(l): 43-82.
134. Bounias M., Purdey M. An epidemiological evaluation of a possible link between BSE and pesticide treatments in France. 2001; under peer review.
135. Goldstein A., Aronow L., Kalman S. M., eds Principles of Drug Action: Basis of Pharmacology, 2nd edn. Wiley International Edition. New York: John Wiley, 1974.
136. Pattison 1. H., Jebbett J. N. Spongiform encephalopathy induced in rats and guinea pigs by cuprizone. -Exp Mol Pathol 1969; 10 (3): 274-287
137 Yang Z. R, Morrow J., Aiping W, Roberts L, Dettbarn W D. Diispropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo. Biochem Phannacol 1996; 52: 3 5 7-3 6 1.
138. Bagchi D., Bagchi M., Hassoun E., Stohs S. In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology 1995; 104:129-140.
139. Myshkin V., Vakarina A., Bashkatov S., Sofronov G., Enikeev D. Postintoxication hypothermia and free radical lipid oxidation in the brain and heart of rats poisoned with OP cholinesterase inhibitors. Bull Exper Biol Med 1992; 113(5): 493-494.
140. Hai D., Varga S., Matkovics B. OP effects on antioxidant system of carp and catfish. Comp Biochem Physiol 1997; 117C(I): 83-85.
141. Matkovics R, Szabo L., Mindszenty L., Ivan J. The effects of OP pesticides on some liver enzymes and lipid peroxidation. Gen Phannacol 1980; 11: 353-355.
142.Chopra A., Ahuja S., Gupta. R, Nagpal S. Histopathological and lipid changes in various organs of chicks
caused by acute and chronic toxicity of metasystox-R and Lebaycid. Zbl Yet Med A 1979; 26:822-834.
143. Gordon L, Abdulla E., Campbell L, Whatley S. Phosmet induces up-regulation of the surface expression of prion protein. Neuroreport. May 1998; 9: 1391-1395.
144. Karlin S., Zhan-Yang Z., Karlin K. D. The extended environment of mononuclear metal centres in protein structures. Proc Natl Acad Sci USA 1997; Dec 94: 14225-14230.

Back to the Science page


Copyright ©  Mark Purdey & Equofax 2002-2008
Comments and feedback to the webmaster

Hit Counter

Design by Equofax
Last updated 09-Feb-2007